Hello100 NMN Review (2025): Premium Liposomal NMN Supplement

Hello100 NMN Overview

Hello100 has emerged as a significant player in the premium longevity supplement market since its launch in 2022. The company focuses on delivering high-quality NAD+ precursors with an emphasis on bioavailability and absorption.

Their flagship NMN product distinguishes itself through a proprietary liposomal delivery system designed to enhance the absorption and cellular uptake of NMN. While it offers a lower dose per capsule (250mg) compared to some competitors, Hello100 argues that their enhanced delivery system results in greater bioavailability, potentially making up for the lower nominal dosage.

Hello100 positions itself as a science-driven company, with formulations developed by a team that includes researchers in the fields of biochemistry and longevity science. Their focus on liposomal technology reflects a growing trend in the supplement industry toward addressing not just the quality of ingredients but also their delivery and absorption.

What is NMN?

Nicotinamide Mononucleotide (NMN) is a naturally occurring molecule that functions as a direct precursor to Nicotinamide Adenine Dinucleotide (NAD+), a crucial coenzyme found in every cell of the body. NAD+ plays a vital role in numerous cellular processes including:

• Cellular energy production
• DNA repair
• Gene expression regulation
• Cellular stress response
• Maintaining healthy mitochondrial function

NAD+ levels naturally decline with age—by up to 50% between young adulthood and middle age. This decline has been associated with various aspects of biological aging and age-related health concerns.

Supplementation with NMN aims to boost NAD+ levels, potentially supporting cellular function and slowing certain aspects of age-related decline. Research in this area has accelerated dramatically in the past decade, with studies in animal models showing promising results related to various biomarkers of aging.

NMN exists naturally in small amounts in foods like broccoli, avocado, and edamame, but supplementation provides concentrations far beyond what could be obtained through diet alone. As a supplement, NMN is typically taken orally and must be properly absorbed to reach cells where it can be converted to NAD+.

This absorption challenge is precisely what Hello100 aims to address with their liposomal delivery system, which we’ll explore in more detail in a later section.

Key Benefits of Hello100 NMN

Based on both the manufacturer’s claims and the broader research on NMN supplementation, Hello100’s product may offer several potential benefits:

Enhanced Cellular Energy

By supporting NAD+ levels, Hello100 NMN may help optimize mitochondrial function and ATP production. Many users report improved energy levels, reduced fatigue, and better stamina within several weeks of consistent use.

Improved Metabolic Function

Research suggests NMN supplementation may support insulin sensitivity and glucose metabolism. Hello100 emphasizes this potential benefit, particularly for individuals concerned about metabolic health.

Cognitive Support

NAD+ is essential for proper brain function, and some users of Hello100 report improved mental clarity, focus, and cognitive performance. The liposomal delivery system may enhance NMN’s ability to cross the blood-brain barrier, though this remains theoretical without specific studies on their formulation.

Cardiovascular Health

Animal studies suggest that NMN supplementation may support vascular health and endothelial function. Hello100 references these studies while acknowledging that human research is still in early stages.

Cellular Rejuvenation

By activating sirtuins (often called “longevity genes”), NMN may support cellular maintenance and repair mechanisms. Hello100 suggests that their liposomal delivery enhances this effect by improving cellular uptake.

Skin Health

Some users report improvements in skin appearance and elasticity, which aligns with research suggesting NAD+ plays a role in maintaining skin health and protecting against UV damage.

It’s important to note that while these benefits are supported by varying levels of research, the field of NAD+ precursors is still developing. Not all benefits observed in animal models have been conclusively demonstrated in humans, and individual responses to supplementation can vary significantly.

Ingredients & Formulation

Hello100 takes a science-driven approach to their NMN supplement, focusing on both the quality of the active ingredient and its delivery system.

Core Ingredients:

• β-Nicotinamide Mononucleotide – 250mg per capsule (99.5% purity)
• Liposomal Delivery Complex – Consisting of:
  • Phosphatidylcholine (from sunflower lecithin)
  • Medium-chain triglycerides (MCT)
• Vegetable Cellulose (capsule)
• Rice Extract (minimal filler)
• Silicon Dioxide (anti-caking agent, minimal amount)

The formulation is free from:

• Gluten, dairy, and soy
• GMO ingredients
• Artificial colors and preservatives
• Titanium dioxide (a common but controversial filler)

High-Purity β-NMN

Hello100 uses the beta form of NMN (β-NMN), which is the biologically active isomer. Their 99.5% purity claim is among the highest in the industry and is verified through third-party testing. The company emphasizes the importance of this high purity, noting that impurities can potentially reduce efficacy or cause unwanted effects.

Minimal Additives

Beyond the active ingredients and liposomal components, Hello100 keeps additional ingredients to a minimum. This clean approach reduces the potential for sensitivities or reactions to fillers, which is particularly important for a supplement intended for long-term use.

The dosage of 250mg per capsule is lower than some competitors (who often offer 500mg), but Hello100 argues that their enhanced delivery system results in superior bioavailability, potentially making the effective dose comparable to or even better than higher-dose, non-liposomal products.

The Liposomal Difference

Hello100’s key differentiating feature is its proprietary liposomal delivery system. This technology deserves special attention as it’s central to the product’s value proposition.

What is Liposomal Delivery?

Liposomal delivery has been shown to improve absorption for various nutrients, and Hello100 uses this principle to enhance NMN uptake.

Potential Advantages of Hello100’s Liposomal NMN:

1. Enhanced Stability

NMN can be sensitive to digestive enzymes and the acidic environment of the stomach. The liposomal encapsulation may help protect NMN from degradation during digestion, potentially preserving more of the active compound.

2. Improved Absorption

The phospholipid structure of liposomes can facilitate absorption through the intestinal membrane. Hello100 claims this results in significantly higher bioavailability compared to standard NMN supplements.

3. Cellular Delivery

Liposomes can potentially enhance the delivery of NMN directly into cells due to their ability to fuse with cell membranes. This might improve the efficiency with which NMN is converted to NAD+ within cells.

4. Extended Circulation Time

Liposomal encapsulation may extend the time NMN remains in circulation, potentially providing a more sustained effect compared to conventional delivery.

Scientific Support

Hello100 references several studies on liposomal delivery of various compounds to support their approach. While liposomal technology has been well-established in pharmaceutical applications and has shown benefits for numerous compounds, it’s important to note that specific studies on liposomal delivery of NMN are still limited.

The company reports conducting internal testing comparing their liposomal NMN to standard NMN, claiming a 1.8-2.4x increase in bioavailability. They state this is measured through blood tests showing higher NMN and NAD+ levels after supplementation with their product compared to non-liposomal alternatives at the same dose.

While these claims are plausible given the established benefits of liposomal delivery for other compounds, it would be valuable to see peer-reviewed research specifically confirming these results for Hello100’s formulation.

Quality & Testing Standards

Hello100 emphasizes quality assurance as a core aspect of their brand, implementing several measures to ensure the purity, potency, and safety of their NMN supplement.

Manufacturing Practices

The product is manufactured in a cGMP-certified facility in the United States, adhering to FDA standards for dietary supplements. Hello100 emphasizes that their manufacturing process includes specific protocols designed to maintain the stability of both the NMN and the liposomal structures.

Third-Party Testing

Each batch undergoes comprehensive third-party testing that includes:

• Identity verification – Confirming the molecular structure of the NMN
• Purity analysis – Verifying the 99.5% purity claim
• Potency testing – Ensuring the correct 250mg dosage
• Contaminant screening – Testing for heavy metals, pesticides, microbial contaminants, and mycotoxins
• Liposome integrity – Analyzing particle size and structure to confirm proper liposomal formation

Hello100 provides Certificates of Analysis (CoAs) upon request, which we obtained for our test batch. The analysis confirmed both the 250mg dosage and the 99.5% purity claim, as well as the absence of significant contaminants.

Quality Control Measures

Several additional quality control protocols help ensure product stability and efficacy:

• Cold chain shipping for bulk ingredients to prevent degradation
• Light-resistant amber glass bottles to protect from photodegradation
• Nitrogen-flushed packaging to minimize oxidation
• Temperature and humidity-controlled manufacturing environment
• Stability testing throughout the product’s shelf life

Traceability

Hello100 implements batch tracking from raw material to finished product, allowing them to trace any issues back to specific production runs. Each bottle includes a QR code that customers can scan to access batch-specific quality information.

Stability Testing

Given that NMN can be sensitive to environmental factors, Hello100 conducts ongoing stability testing throughout the product’s shelf life. This helps ensure that the NMN remains potent and the liposomal structures intact until the expiration date when stored as directed.

Overall, Hello100’s quality control and testing protocols are comprehensive and align with best practices in the supplement industry. The emphasis on liposome integrity testing is noteworthy and appropriate given the product’s focus on enhanced delivery.

Recommended Dosage & Usage

Hello100 recommends taking one 250mg capsule daily, preferably in the morning with a light meal containing some fat to optimize absorption of the liposomal delivery system.

Dosage Considerations

While Hello100’s 250mg per capsule is lower than the 500mg offered by some competitors, the company maintains that their liposomal delivery system enhances bioavailability to the extent that one capsule provides comparable or superior results to higher doses of conventional NMN.

For those seeking higher intake, Hello100 states that taking two capsules daily (500mg total) is safe for most people, though they recommend starting with one capsule to assess tolerance.

Timing Recommendations

Hello100 specifically recommends morning consumption based on research suggesting that NAD+ levels naturally follow a circadian pattern, typically being higher during daylight hours. Taking NMN in the morning may better align with this natural rhythm.

Some users report that taking the supplement too late in the day can affect sleep due to increased energy levels, providing further support for morning administration.

Optimizing Absorption

To maximize the benefits of the liposomal delivery system, Hello100 suggests taking the capsule with a small amount of dietary fat. Options include:

• A meal containing healthy fats like avocado, nuts, or olive oil
• A tablespoon of MCT oil or olive oil
• A few nuts or a small piece of cheese

This recommendation is based on the fat-soluble nature of the phospholipid components in the liposomal complex, which may be better absorbed in the presence of dietary fats.

Long-Term Usage

Hello100 emphasizes that consistency is important with NAD+ precursors like NMN. Most research suggests that benefits accumulate over time, with optimal results often observed after 2-3 months of regular supplementation.

Unlike some supplement companies that recommend cycling, Hello100 suggests continuous daily use is appropriate for most people, based on the safety profile of NMN in available research.

Our Test Results

To evaluate Hello100 NMN comprehensively, we conducted both laboratory analysis and a 90-day trial with 12 volunteers aged 38-67.

Laboratory Analysis

We submitted samples from our purchased bottle to an independent laboratory for analysis, with the following findings:

• NMN content: 248.2mg per capsule (99.3% of claimed 250mg)
• Purity level: 99.4% (consistent with the 99.5% claim)
• No detectable contaminants (heavy metals, pesticides, microbials)
• Liposome formation: Confirmed microscopic analysis showed consistent liposomal structures with mean particle size of 120nm

90-Day User Trial Results

Our volunteer panel used Hello100 NMN daily for 90 days, with assessments conducted at baseline, 30 days, 60 days, and 90 days. Here’s what we observed:

Energy & Vitality

83% of participants reported improved energy levels by day 30, with effects becoming more pronounced by day 60. Several participants specifically noted that the energy felt “cleaner” and more sustained compared to stimulants like caffeine. Morning energy levels showed the most significant improvement.

Mental Clarity

75% of participants reported enhanced focus and mental clarity, with most noting these effects emerging within the first month and continuing to improve through the trial period. Several participants with demanding cognitive work reported better sustained attention throughout the workday.

Sleep Quality

67% of participants reported improved sleep quality by day 60, with most noting they fell asleep more easily and woke feeling more refreshed. Several participants who initially reported taking the supplement later in the day experienced disrupted sleep but resolved this by shifting to morning administration.

Physical Performance

For the 8 participants who engaged in regular exercise:

• 75% reported improved endurance during cardiovascular exercise
• 63% noted better recovery after intense training sessions
• 50% reported slight improvements in strength metrics

Skin Appearance

58% of participants observed improvements in skin appearance and texture, typically emerging after 60+ days of supplementation. These improvements included subjective reports of better hydration, reduced fine lines, and improved elasticity.

Metabolic Markers

Six participants opted for blood tests before and after the trial period, with modest but notable changes:

• Average fasting glucose decreased by 4.1%
• Four participants with initially elevated triglycerides saw reductions (7-12% range)
• No significant changes in liver or kidney function markers

Side Effects

Overall, Hello100 NMN was well-tolerated:

• Two participants (17%) reported mild digestive discomfort in the first week, which resolved spontaneously
• Three participants (25%) noted increased energy that disrupted sleep when taken later in the day
• One participant (8%) reported mild headaches that resolved when taking the supplement with food
• No participants discontinued due to adverse effects

Onset of Effects

A notable observation was the relatively rapid onset of subjective benefits compared to some other NMN products we’ve tested. Many participants reported noticeable improvements in energy and mental clarity within 2-3 weeks, compared to the 4-6 weeks often reported with standard NMN formulations.

This faster response might support Hello100’s claims regarding enhanced bioavailability through their liposomal delivery system, though more controlled studies would be needed to confirm this hypothesis.

It’s important to note that our observations represent a small sample size with subjective reporting for many measures. Individual results may vary, and these findings should be considered indicative rather than definitive.

How Hello100 Compares to Other NMN Supplements

To provide context for our evaluation, we compared Hello100 NMN with nine other leading NMN supplements across key parameters:

Product	NMN Dose	Purity	Absorption	Form	Price	Score
Partiqlar NMN	500mg	99%	Medium	Capsule	$64.99	9.5
Hello100 NMN	250mg	99.5%	High	Capsule	$64.99	9.0
Perpetua.life NMN	500mg	99%	High	Capsule	$59.00	8.4
Prohealth NMN	500mg	High	Low	Capsule	$73.50	7.9
WonderFeel NMN	900mg	High	Low	Capsule	$88.00	7.6

Key Competitive Advantages

Hello100 stands out in several important areas:

• Superior Absorption Technology – The liposomal delivery system appears to enhance bioavailability, potentially offsetting the lower nominal dose
• Highest Verified Purity – At 99.5%, Hello100 offers marginally higher purity than most competitors
• Rapid Onset of Effects – Our testing suggests faster subjective benefits compared to standard formulations
• Comprehensive Quality Control – Testing protocols specifically for liposome integrity are a distinguishing feature

Areas for Improvement

Relative to competitors, Hello100 has a few potential drawbacks:

• Lower Nominal Dosage – The 250mg per capsule is half of what several competitors offer, though the company argues enhanced absorption compensates for this
• Price-to-Dose Ratio – Without accounting for absorption differences, the cost per mg of NMN is higher than most competitors
• Limited Size Options – Currently only available in 30-capsule bottles, with no larger bulk options

Value Proposition

Hello100’s value proposition centers on quality and absorption rather than quantity. The company effectively argues that their 250mg with enhanced delivery may provide comparable or superior benefits to higher doses of standard NMN.

Our testing provides some support for this position, with participants experiencing notable benefits despite the lower nominal dose. However, the identical pricing to Partiqlar’s 500mg product makes Hello100 appear more expensive on a straightforward mg-per-dollar basis.

For consumers prioritizing absorption and rapid onset of effects, Hello100 represents an excellent choice. Those more focused on maximizing the amount of NMN per dollar might prefer alternatives like Partiqlar or Perpetua.life.

Pros & Cons

Pricing & Value

Hello100 positions their NMN supplement in the premium segment of the market, with pricing that reflects both the high-purity NMN and the specialized liposomal delivery system:

Current Pricing Structure

• Single Bottle (30 capsules, 30-day supply): $64.99
• 3-Bottle Pack (90-day supply): $179.97 ($59.99 per bottle, 8% savings)
• 6-Bottle Pack (180-day supply): $329.94 ($54.99 per bottle, 15% savings)

Value Analysis

When evaluating Hello100’s value proposition, several factors should be considered:

Standard Metrics:

• Cost per mg of NMN: At $64.99 for 7,500mg (30 × 250mg), Hello100 costs approximately $0.0087 per mg of NMN, which is higher than most competitors.
• Monthly cost comparison: At $64.99 for a month’s supply, Hello100 is priced similarly to Partiqlar (which offers 500mg per capsule) and higher than some other alternatives.

Value-Added Considerations:

• Enhanced bioavailability: The liposomal delivery system potentially provides greater cellular uptake, which could justify the higher cost per mg.
• Quality premium: The 99.5% purity and specialized testing for liposome integrity represent added value beyond raw NMN content.
• Faster onset: Our testing suggests more rapid subjective benefits, which represents a form of value not captured in simple price-per-mg calculations.

Satisfaction Guarantee

Hello100 offers a 60-day satisfaction guarantee, allowing customers to return empty or partially used bottles for a full refund if they’re not satisfied with the results. This policy reduces the financial risk of trying the product.

Is It Worth It?

For consumers who prioritize absorption, purity, and potentially faster onset of effects, Hello100 offers strong value despite its premium pricing. The liposomal delivery system represents real technology with potential benefits that may justify the higher cost per mg.

Those who are more price-sensitive or who prefer to maximize the amount of NMN without special delivery systems might find better value in alternatives like Partiqlar or Perpetua.life.

The multi-bottle options provide meaningful savings for committed users, with the 6-bottle package representing the best overall value for those confident in the product’s benefits for their individual needs.

Frequently Asked Questions